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| Article Name : | | | TUMOR NECROSIS FACTOR (TNF-ά), INTERLEUKIN–6 AND NITRIC OXIDE SERUM LEVELS AMONG EGYPTIAN CHILDREN WITH CHRONIC RENAL FAILURE | | Author Name : | | | Essam Shawky A.E.H. Khattab , Khadega Kamel El Gohary and Hala Hassen El Deeb | | Publisher : | | | Ashok Yakkaldevi | | Article Series No. : | | | ROR-1275 | | Article : | |  | Author Profile | | Abstract : | | | Renal failure is characterized by the accumulation of nitrogenous waste products (urea and creatinine), and the inability to regulate fluid and electrolyte homeostasis. The glomerular filtration rate (GFR) must usually decline by 50% or more, before clinical significant increase in the serum creatinine and urea concentration. The present study were conducted through 60 Egyptian children, ages from (2-14) years, divided into two groups; 40 patients were diagnosed as renal failure and 20 healthy control group.The objective of our present study was to estimate the serum level of TNF-α and IL-6 and to evaluate the possible role of nitric oxide in these patients.The results showed highly significant increase in TNF-α, and IL-6. In contrast, nitric oxide showed highly significant decrease in chronic renal failure group compared to healthy control group. Correlation coefficient between TNF-α & IL-6 and urea, creatinine, phosphorous & potassium, showed highly positive significant correlation. Correlation coefficient between nitric oxide, and urea, creatinine, phosphorous & potassium, showed highly negative significant correlation. | | Keywords : | | - Interleukin-6,Interleukin-6,Interleukin-6
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