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| Article Name : | | | PROTECTIVE EFFECT OF GHREL IN AGAINST RENAL ISCHEMIA/REPERFUSION-INDUCED OXIDATIVE REMOTE ORGAN INJURY IN RATS | | Author Name : | | | Elsayed Emara , Ahmida H.S. Mohamed , Isam Denna and Esam Elshweehy | | Publisher : | | | Ashok Yakkaldevi | | Article Series No. : | | | ROR-985 | | Article : | |  | Author Profile | | Abstract : | | | Background and aim: Oxygen free radicals and cytokines are considered to be important components involved in the pathophysiological tissue alterations observed during ischemia/reperfusion (I/R). Based on the anti-oxidant and anti-inflammatory effects of ghrelin, we investigated the putative protective role of ghrelin against I/R-induced oxidative remote organ injury. Materials and methods: Male albino rats were subjected to either sham operation or bilateral renal artery clamping for 45 min and reperfusion for 24 h to induce I/R damage. Ghrelin (100 µg/kg) or saline was injected subcutaneously six times before ischemia and three times after ischemia every 8 hr. At the end of the reperfusion period, the rats were decapitated and hepatic tissue were removed for biochemical analyses of: malondialdehyde (MDA), an end product of lipid peroxidation; the activity of antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT); the myeloperoxidase (MPO) activity, as an indirect index of neutrophil infiltration and the level of pro-inflammatory cytokines (TNF-α and IL-1β). | | Keywords : | | - Oxidative remote organ injury
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