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| Article Name : | | | IN VITRO STUDIES ON LUFFA CYLINDRICA SEEDS FOR ANTHELMINTIC AND ANTIOXIDANT PROPERTIES | | Author Name : | | | Madan singh , Bhanu Priya , Amit Kumar Singh and Neelam Soni | | Publisher : | | | Ashok Yakkaldevi | | Article Series No. : | | | ROR-946 | | Article : | |  | Author Profile | | Abstract : | | | Purpose: To investigate the antioxidant and anthelmintic activities of ethanolic, methanolic and chloroform extracts of Luffa cylindrica seeds commonly used in South Asia, South Europe and Africa traditional medicine for the treatment of various ailments. Methods: The extracts were obtained by successive extraction (using Soxhlet Apparatus) using Petroleum-ether (60-80?c), Benzene, Solvent ether, Chloroform, Acetone, Ethanol and Methanol as solvent. The antioxidant effect of the extracts was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Superoxide Scavenging Assay. The anthelmintic activity of the extracts was tested against Indian Earthworm (Pheretima posthuma) .Various concentrations of Ethanol, Methanol and Chloroform extract (40, 60, 80 mg/ml) of leaves of Luffa cylindrica were tested in the bioassay, which involve determination of time for paralysis and time for death of worms. Mebendazole was included as references standard. Results: The ethanolic extract showed significant in vitro antioxidant activity in comparison to the standard antioxidant (ascorbic acid) methanolic, chloroform extract. The drug has been found to have anthelmintic activity in the ethanolic extract, methanolic extract and the chloroform extract but the most significant activity has been found in the ethanolic extract. It was found to be comparable with the standard drug Mebendazole. Conclusion: These results suggest that Luffa cylindrica have potent antioxidant and anthelmintic activities. Further study is necessary for isolation and characterization of the active antioxidant agents which can be used to treat various oxidative stress-related diseases. | | Keywords : | | - Free radicals
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