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Article Details :: |
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| Article Name : | | | SYNTHESIS, MOLECULAR MODELLING AND BIOLOGICAL EVALUATIONS OF NOVEL PYRROLIDINEDERIVATIVES AS POTENTIAL CYCLOOXYGENASE-2 (COX-2) INHIBITORS | | Author Name : | | | Dr. Kedar N. A. and Kulkarni P. V. | | Publisher : | | | Ashok Yakkaldevi | | Article Series No. : | | | ROR-13045 | | Article : | |  | Author Profile | | Abstract : | | | Towards the development of selective cyclooxygenase-2 inhibitors, a series of pyrrolidinederivatives is described. All the compounds containing sulfonamide, ester, nitrile, acid, amide and urea functionalities were computationally screened and binding affinity scores for all synthesized compounds with COX-1 and COX-2 were compared. | | Keywords : | | - pyrrolidinederivatives,cyclooxygenase-2,
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